5-Hydroxy omeprazole standards

Omeprazole is primarily hydroxylated by CYP2C19 into 5-hydroxyomeprazole. 5-Hydroxy omeprazole retains the general structure of Omeprazole with an additional hydroxyl group on the pyridine ring, increasing its hydrophilicity. 5-Hydroxyomeprazole is an inactive metabolite, meaning it does not contribute to Omeprazole’s pharmacological effect of inhibiting stomach acid production. Its formation is a key step in Omeprazole clearance. 

The enzyme CYP3A4 also contributes to metabolism but mainly by forming sulfone metabolites. Omeprazole sulfide and 5-Hydroxy Omeprazole sulfide are reported as metabolites and/or  as potential impuritties in commercial preparations of Omeprazole. We will be happy to provide you  5-hydroxy omeprazole , 5-hydroxy omeprazole D3 and 5-Hydroxy Omeprazole sulfide as analytical standards for your studies.

  • Hydroxy omeprazole

Product citations

  1. Improving CYP2C19 phenotyping using stereoselective omeprazole and 5‐hydroxy‐omeprazole metabolic ratios
    K Abouir, E Varesio, J Déglon… - Basic & Clinical …, 2024 - Wiley Online Library
    … Over time, there has been a transition from utilizing mephenytoin to omeprazole (OME) as a
    … to 5-hydroxyomeprazole (referred to in this article as OHOME), 3-hydroxyomeprazole, 5-O-…
  2. Stereoselective separation of omeprazole and 5-hydroxy-omeprazole using dried plasma spots and a heart-cutting 2D-LC approach for accurate CYP2C19 …
    K Abouir, C Samer, R Landry, E Varesio… - … of Chromatography B, 2024 - Elsevier
    … According to the manufacturer, omeprazole enantiomers are separated in normal mode with
    … of the hydroxy metabolite of S-omeprazole was ten times lower than that of R-omeprazole [1]…
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