Custom Synthesis
@tMolecule company provides a variety of organic custom synthesis services to pharmaceutical, chemical, or agrochemical companies and for other customers around the world. @rtMolecule synthesize small molecules which require complex chemistry and technical capabilities from milligrams to grams scale. Our expertise includes Stable isotopes, Metabolites, Impurities, APIs and key intermediates, micropollutants or emerging pollutants, and more.
For Custom Synthesis Services
Drug Metabolites
Phase 1 oxidation of heteotomes, acitvate and unactive C-H positions.
Aromatic hydroxylation.
Hydroxylation and ketonylation.
Benzylic and aliphatic oxidation.
Alcohol and amine (N-O) oxidation.
Phase 2 Chemical conjugation of Alcohols, phenols, amines, and acids.
O- acyl and N glucuronide.
O- and acyl glucoside.
O-and N sulphate.
O-and N acetyl, methyl, and glycine.
Stable Isotope-Labeled Compounds
Isotope level incorporation (Deuterium, 13C, 15N, 18O or mixed) is kept to meet customer's needs for quantitative MS assays.
Labelled API Reference Standards.
Labelled Metabolites synthesis.
Impurities Stable Isotopes.
Environnemental Labelled Standards.
Chemical Probes
Design of cleavable and non-cleaveable linkers small-molecule probes to validate targets and biology.
Biotinylation.
Fluorescent tags.
Astaxanthin tags.
More small molecule tags.
N-Nitroso Compounds (NOC)
N-nitrosamine contamination in drugs has recently caused great concern and the attention of regulatory agencies.
Nitroso of primary amines.
Nitroso of secondary amines.
Nitroso of aromatic amines.
Impurities
Organic impurities can arise during the manufacturing process and/or storage of the new drug substance.
By-products .
Degradation product.
Reagents, ligands, and catalyst.
Starting materials .
Food and Environmental
Synthesis of analytical materials to detect, identify, and quantify chemical residues that may be present as environmental contaminants.
Labeled biocides.
Biocide metabolites.
Biocide Impurities. Food contact materials.
Custom Synthesis
Custom chemical synthesis with innovative solutions for complex and challenging projects.
Online products
Find Stable Isotopes (D,13C, 15N), Metabolites, Impurities and Environmental standards.
Re-analysis
Our Certificate of Analysis gives you a detailed summary of the quality of your product.
Research Projects
We are dedicated to providing customers with exceptional products and services.
Features of Our Custom Synthesis Services
Expertise and Experience
Facilities
General Information
Stable Isotopes - Abundances %
The key elements in organic chemistry are carbon (C), hydrogen (H), nitrogen (N), oxygen (O), phosphorus (P), sulfur (S), chlorine (Cl), and bromine (Br). These elements naturally occur as mixtures of isotopes, which significantly influence the isotope distribution.
5-Hydroxy omeprazole standards
Omeprazole is primarily hydroxylated by CYP2C19 into 5-hydroxyomeprazole. 5-Hydroxy omeprazole retains the general structure of Omeprazole with an additional hydroxyl group on the pyridine ring, increasing its hydrophilicity.